Detection of visible light

Across TCGA cell cohorts, RNA activity of the Detection of visible light pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CWF19L1, PPEF1, and CD2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CWF19L1 grouped by Detection of visible light-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CWF19L1 →	-0.500	-1.767	.009	<.001	3	3
SKIN	PPEF1 →	-0.239	-1.767	.003	<.001	3	2
SKIN	CD2 →	-0.366	-1.767	.009	<.001	3	2
SKIN	CFAP94 →	+0.280	+1.767	.002	<.001	3	2
SKIN	HAT1 →	+0.133	+1.767	.004	<.001	3	2
SKIN	CCDC146 →	-0.170	-1.767	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CWF19L1 by Detection of visible light activity — SKIN

Explore this box plot interactively →