Detection of visible light

Across TCGA pan-cancer cohorts, RNA activity of the Detection of visible light pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 53 member genes.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher Detection of visible light pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and UVM, show the opposite pattern, with higher activity associated with better survival.

LUAD, HNSC, and READ are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.894	0.783	.001	79	view →
HNSC	DFS	Tertile	III,IV	0.565	0.754	.001	56	view →
READ	OS	Median	All	0.472	0.845	.002	27	view →
UVM	OS	Median	All	1.000	0.762	.006	19	view →
LIHC	OS	Quartile	II,III,IV	0.475	0.736	.008	17	view →
KIRP	OS	Median	II,III,IV	0.873	0.355	.008	15	view →
KICH	DFS	Quartile	All	0.529	1.000	.008	14	view →
THCA	DFS	Median	IV	0.548	1.000	.004	14	view →
COAD	OS	Tertile	IV	0.628	0.282	.027	13	view →
STAD	OS	Quartile	II,III,IV	0.564	0.713	.024	12	view →
SKCM	OS	Tertile	IV	0.660	0.922	.023	10	view →
ACC	OS	Median	II,III,IV	0.239	0.786	.010	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0009584–LUAD (OS)

Open the LUAD breakdown →