Gamma-aminobutyric acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Gamma-aminobutyric acid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH1A1, BMP2K_S728, and FGD3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-aminobutyric acid biosynthetic process activity versus ALDH1A1 in HNSC (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ALDH1A1 →	+0.853	+0.122	<.001	<.001	3	8
LSCC	BMP2K_S728 →	+0.663	+0.107	<.001	<.001	3	7
BRCA	FGD3 →	+0.616	+0.122	<.001	<.001	3	7
GBM	SYK →	+0.429	+0.106	.004	.001	3	6
LSCC	WIPF1 →	+0.334	+0.093	<.001	.001	3	6
LSCC	BTK →	+0.486	+0.106	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009449 vs ALDH1A1 — HNSC

Explore this scatter interactively →