Gamma-aminobutyric acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Gamma-aminobutyric acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC71L, RUNX2, and NIBAN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-aminobutyric acid biosynthetic process activity versus CCDC71L in GBM (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CCDC71L →	-1.162	-0.294	<.001	<.001	3	4
GBM	RUNX2 →	-0.591	-0.222	.001	<.001	3	4
GBM	NIBAN2 →	-0.552	-0.179	<.001	<.001	3	4
GBM	RGS16 →	-0.795	-0.258	.002	<.001	3	4
CCRCC	SNAI3-AS1 →	-0.220	-0.179	.003	.005	3	4
GBM	RBMS1 →	-0.537	-0.183	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009449 vs CCDC71L — GBM

Explore this scatter interactively →