Gamma-aminobutyric acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Gamma-aminobutyric acid biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC1A3, GAD2, and ABAT, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC1A3 grouped by Gamma-aminobutyric acid biosynthetic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC1A3 →	-0.220	-1.004	<.001	<.001	3	11
SOFT_TISSUE	GAD2 →	-0.252	-1.468	.008	<.001	2	8
CNS	ABAT →	-0.277	-1.273	<.001	<.001	2	8
LIVER	NIP7 →	+0.460	+2.009	.001	.003	3	4
URINARY_TRACT	PHF13 →	+0.200	+1.665	<.001	<.001	3	4
URINARY_TRACT	TAL2 →	-0.237	-1.792	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC1A3 by Gamma-aminobutyric acid biosynthetic process activity — BLOOD_Leukemia

Explore this box plot interactively →