Gamma-aminobutyric acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Gamma-aminobutyric acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADIPOR1, EPB41L4A, and POLR3G, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADIPOR1 grouped by Gamma-aminobutyric acid biosynthetic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ADIPOR1 →	+0.532	+1.194	.005	.002	3	5
LUNG_NSCLC_LUAD	EPB41L4A →	+1.346	+0.989	<.001	.001	3	4
LUNG_NSCLC_LUAD	POLR3G →	-0.596	-0.691	.007	.001	3	4
LUNG_NSCLC_LUAD	MPHOSPH6 →	-0.686	-0.927	.001	.001	3	4
LUNG_NSCLC_LUAD	ZIC5 →	-0.728	-0.943	<.001	<.001	3	4
BREAST	CGAS →	-1.865	-1.051	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADIPOR1 by Gamma-aminobutyric acid biosynthetic process activity — LUNG_SCLC

Explore this box plot interactively →