Gamma-aminobutyric acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Gamma-aminobutyric acid biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAS1, EIF5A2, and RPS9, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OAS1 grouped by Gamma-aminobutyric acid biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OAS1 →	+0.240	+1.715	<.001	<.001	3	2
LARGE_INTESTINE	EIF5A2 →	+0.212	+1.494	.001	<.001	3	2
LARGE_INTESTINE	RPS9 →	+0.376	+1.883	.002	<.001	3	1
LARGE_INTESTINE	CCR9 →	+0.246	+1.266	.001	.002	3	1
LARGE_INTESTINE	PHC3 →	-0.206	-1.494	.003	<.001	3	1
LARGE_INTESTINE	KCNK18 →	+0.170	+1.494	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OAS1 by Gamma-aminobutyric acid biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →