Gamma-aminobutyric acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Gamma-aminobutyric acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP8, XRCC2, and DGAT2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-aminobutyric acid biosynthetic process activity versus DUSP8 in LARGE_INTESTINE (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DUSP8 →	+2.155	+1.758	.005	<.001	3	2
LARGE_INTESTINE	XRCC2 →	-1.357	-1.454	.009	.007	3	2
LARGE_INTESTINE	DGAT2 →	+2.152	+1.626	.009	<.001	3	2
LARGE_INTESTINE	NEFH →	-0.082	-1.762	.003	<.001	3	1
LARGE_INTESTINE	TRIB3 →	+2.337	+1.748	.008	<.001	3	1
LARGE_INTESTINE	FA2H →	+2.360	+1.659	.001	<.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009449 vs DUSP8 — LARGE_INTESTINE

Explore this scatter interactively →