Gamma-aminobutyric acid metabolic process

Across TCGA cell cohorts, RNA activity of the Gamma-aminobutyric acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH5A1, ALDH1A1, and GKAP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-aminobutyric acid metabolic process activity versus ALDH5A1 in OVARY (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ALDH5A1 →	+0.992	+1.017	.005	.004	2	7
LARGE_INTESTINE	ALDH1A1 →	+4.537	+0.814	<.001	.006	3	6
PANCREAS	GKAP1 →	+1.557	+1.866	.004	<.001	3	4
URINARY_TRACT	P4HB →	-0.879	-1.904	.004	<.001	3	4
CNS	ALKBH5 →	+0.440	+2.033	.001	<.001	3	3
CNS	PSME1 →	-0.832	-1.897	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009448 vs ALDH5A1 — OVARY

Explore this scatter interactively →