Putrescine metabolic process

Across TCGA patient cohorts, RNA activity of the Putrescine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDGFRL, UBTD1, and GOLT1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Putrescine metabolic process activity versus PDGFRL in COAD (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PDGFRL →	-1.131	-0.100	.001	.002	2	5
HNSC	UBTD1 →	-0.677	-0.789	.007	.002	2	5
UCEC	GOLT1B →	-0.438	-0.167	<.001	<.001	3	4
BRCA	KRT7 →	-1.380	-0.295	.006	.003	3	4
UCEC	SDR42E2 →	+0.579	+0.164	.003	.002	3	4
BRCA	ADAMTS2 →	-1.146	-0.278	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009445 vs PDGFRL — COAD

Explore this scatter interactively →