Putrescine metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Putrescine metabolic process pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Putrescine metabolic process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and READ, show the opposite pattern, with higher activity associated with better survival.

KIRC, UVM, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.709	0.565	<.001	83	view →
UVM	DFS	Tertile	III,IV	0.217	1.000	<.001	64	view →
ESCA	OS	Tertile	All	0.470	1.000	.003	48	view →
CHOL	DFS	Tertile	II,III,IV	0.092	0.574	.008	36	view →
UCS	DFS	Quartile	III,IV	0.193	0.517	.018	24	view →
UCEC	DFS	Tertile	IV	0.453	0.933	.002	24	view →
READ	OS	Median	III,IV	0.651	0.280	.004	20	view →
PAAD	OS	Median	II,III,IV	0.758	0.500	.001	17	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	16	view →
STAD	DFS	Tertile	III,IV	0.206	0.483	.034	15	view →
ACC	OS	Tertile	IV	0.344	0.724	.038	12	view →
BLCA	DFS	Median	IV	0.462	0.248	.023	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0009445–KIRC (OS)

Open the KIRC breakdown →