Putrescine metabolic process

Across TCGA cell cohorts, RNA activity of the Putrescine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAT2, AGMAT, and RNASEK, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Putrescine metabolic process activity versus SAT2 in BLOOD_Lymphoma (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SAT2 →	+1.682	+0.184	<.001	<.001	2	14
PANCREAS	AGMAT →	-1.324	-0.159	<.001	.001	3	10
URINARY_TRACT	RNASEK →	+0.889	+0.224	<.001	.001	3	10
SOFT_TISSUE	GABARAP →	+0.682	+0.140	<.001	.003	3	9
BLOOD_Myeloma	SNHG32 →	+1.041	+0.114	<.001	<.001	3	9
CNS	SAT1 →	+1.998	+0.225	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009445 vs SAT2 — BLOOD_Lymphoma

Explore this scatter interactively →