Response to UV

Across TCGA patient cohorts, RNA activity of the Response to UV pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HCCS, FAM160A2, and FAM83E_S351, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to UV activity versus HCCS in PDAC (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HCCS →	-0.238	-0.019	<.001	.001	3	5
LUAD	FAM160A2 →	-0.200	-0.026	<.001	<.001	3	5
LUAD	FAM83E_S351 →	-0.911	-0.023	<.001	<.001	3	5
LUAD	GPX7 →	+0.296	+0.019	.006	.002	3	5
OV	HAPLN3 →	+0.692	+0.030	.006	.002	3	5
LUAD	MLYCD →	-0.312	-0.021	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009411 vs HCCS — PDAC

Explore this scatter interactively →