Response to UV

Across TCGA pan-cancer cohorts, RNA activity of the Response to UV pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 151 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Response to UV pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and BRCA, show the opposite pattern, with higher activity associated with better survival.

HNSC, KIRC, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.742	0.562	<.001	132	view →
KIRC	DFS	Median	All	0.546	0.697	<.001	108	view →
ACC	DFS	Quartile	All	0.274	0.711	<.001	94	view →
UVM	DFS	Median	III,IV	0.305	0.692	.001	76	view →
KICH	DFS	Tertile	All	0.549	0.906	.001	65	view →
LIHC	OS	Median	All	0.695	0.838	<.001	57	view →
LGG	DFS	Median	All	0.587	0.846	<.001	54	view →
KIRP	DFS	Tertile	All	0.557	0.847	<.001	52	view →
BLCA	DFS	Median	IV	0.280	0.581	.002	45	view →
BRCA	DFS	Tertile	III,IV	0.700	0.415	.004	40	view →
MESO	OS	Median	All	0.278	0.491	<.001	38	view →
UCEC	DFS	Median	All	0.792	0.880	.002	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0009411–HNSC (DFS)

Open the HNSC breakdown →