Response to UV

Across TCGA patient cohorts, RNA activity of the Response to UV pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EZH2, LIG1, and GPAT3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to UV activity versus EZH2 in BRCA (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EZH2 →	+0.664	+0.198	.004	<.001	3	3
OV	LIG1 →	+0.609	+0.242	.008	.002	3	3
CCRCC	GPAT3 →	-0.781	-0.158	<.001	<.001	3	3
COAD	CDCA3 →	+0.651	+0.188	<.001	<.001	3	2
COAD	FGF13 →	-0.292	-0.202	.006	.005	3	2
BRCA	CPQ →	-0.831	-0.208	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009411 vs EZH2 — BRCA

Explore this scatter interactively →