Response to UV

Across TCGA cell cohorts, RNA activity of the Response to UV pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BDP1, IKZF1, and RPP25, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BDP1 grouped by Response to UV-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BDP1 →	+0.188	+0.127	.005	.003	3	5
LUNG_NSCLC_LUSC	IKZF1 →	+0.264	+0.149	<.001	.002	3	4
STOMACH	RPP25 →	+0.202	+0.111	<.001	<.001	3	4
LIVER	TUBB →	+0.487	+0.123	.008	.006	3	4
LUNG_SCLC	DAP →	+0.350	+0.186	<.001	.002	3	4
BREAST	AJUBA →	+0.239	+0.131	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BDP1 by Response to UV activity — CNS

Explore this box plot interactively →