Response to UV

Across TCGA cell cohorts, RNA activity of the Response to UV pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAAT1, PROSER3, and CTSH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLAAT1 grouped by Response to UV-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PLAAT1 →	+1.381	+0.111	<.001	.001	3	5
BREAST	PROSER3 →	+0.844	+0.092	.005	.009	3	5
BLOOD_Lymphoma	CTSH →	-6.073	-0.397	.001	.006	3	4
SOFT_TISSUE	FUT8 →	-1.869	-0.147	.002	.001	3	4
LUNG_SCLC	TESMIN →	+2.353	+0.157	<.001	<.001	3	4
LUNG_SCLC	PLPP2 →	+3.314	+0.172	.007	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLAAT1 by Response to UV activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →