Response to cold

Across TCGA cell cohorts, RNA activity of the Response to cold pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AANAT, AURKAP1, and RBM12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AANAT grouped by Response to cold-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AANAT →	-0.189	-0.095	.002	.003	3	6
LARGE_INTESTINE	AURKAP1 →	+0.240	+0.094	.006	<.001	3	5
CNS	RBM12 →	+0.075	+0.074	.009	.002	3	5
LARGE_INTESTINE	KAT7 →	-0.274	-0.084	.001	.001	3	4
OESOPHAGUS	ZNF517 →	+0.395	+0.165	.002	.002	3	4
LUNG_SCLC	MARCHF2 →	+0.228	+0.139	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AANAT by Response to cold activity — OVARY

Explore this box plot interactively →