Response to cold

Across TCGA cell cohorts, RNA activity of the Response to cold pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDRG1, JAG2, and TMBIM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to cold activity versus NDRG1 in KIDNEY (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NDRG1 →	-3.403	-0.172	.001	.005	3	5
BONE	JAG2 →	+3.848	+0.299	.008	.001	3	5
OESOPHAGUS	TMBIM1 →	-1.587	-0.196	<.001	<.001	3	4
KIDNEY	TMEM120A →	-0.865	-0.149	<.001	.009	3	4
BLOOD_Lymphoma	UQCR11 →	+0.778	+0.150	.003	.006	3	4
PANCREAS	CTSA →	-1.141	-0.198	.008	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009409 vs NDRG1 — KIDNEY

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