Response to heat

Across TCGA cell cohorts, RNA activity of the Response to heat pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INO80E, C20orf27, and KIF1C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to heat activity versus INO80E in SKIN (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	INO80E →	+0.388	+0.202	.002	.002	3	5
OVARY	C20orf27 →	+1.041	+0.242	<.001	<.001	3	4
LUNG_NSCLC_LUAD	KIF1C →	+0.831	+0.158	.001	.001	3	4
LUNG_NSCLC_LUAD	PRDX3 →	+0.707	+0.173	.002	<.001	3	4
LUNG_NSCLC_LUAD	GATB →	+0.661	+0.228	.004	<.001	3	4
STOMACH	TM9SF1 →	-0.832	-0.233	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009408 vs INO80E — SKIN

Explore this scatter interactively →