Folic acid-containing compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Folic acid-containing compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRP1B, IRAK1BP1, and SUPT16H, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Folic acid-containing compound biosynthetic process activity versus RRP1B in BLOOD_Lymphoma (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RRP1B →	+0.757	+0.201	<.001	<.001	3	8
SOFT_TISSUE	IRAK1BP1 →	+1.233	+0.296	<.001	.001	3	8
BLOOD_Lymphoma	SUPT16H →	+0.683	+0.202	<.001	<.001	3	7
URINARY_TRACT	ATR →	+0.785	+0.387	.001	.007	3	7
KIDNEY	PMS1 →	+0.694	+0.243	.009	.006	3	6
KIDNEY	NAA25 →	+0.762	+0.308	.005	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009396 vs RRP1B — BLOOD_Lymphoma

Explore this scatter interactively →