Phospholipid catabolic process

Across TCGA patient cohorts, RNA activity of the Phospholipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YPEL2, NAIP, and GVINP1, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipid catabolic process activity versus YPEL2 in TGCT (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	YPEL2 →	+1.467	+0.031	<.001	<.001	3	29
LAML	NAIP →	+1.455	+0.049	<.001	<.001	3	27
TGCT	GVINP1 →	+1.285	+0.032	<.001	<.001	3	27
UCS	TCP11L2 →	+1.052	+0.045	<.001	<.001	3	26
LAML	EIF4EP1 →	+0.895	+0.047	<.001	<.001	3	26
SARC	DOCK8 →	+1.022	+0.024	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009395 vs YPEL2 — TGCT

Explore this scatter interactively →