Phospholipid catabolic process

Across TCGA patient cohorts, RNA activity of the Phospholipid catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ECHS1, PHF11_S17, and TRIP13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipid catabolic process activity versus ECHS1 in CCRCC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ECHS1 →	+0.267	+0.031	.007	.003	3	5
PDAC	PHF11_S17 →	+0.774	+0.042	.001	<.001	3	5
LUAD	TRIP13 →	-0.730	-0.037	<.001	.001	3	5
GBM	FUCA1 →	+0.446	+0.033	<.001	<.001	3	5
LUAD	KIF23 →	-0.687	-0.033	<.001	.005	3	5
PDAC	PBLD →	+0.524	+0.045	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009395 vs ECHS1 — CCRCC

Explore this scatter interactively →