Phospholipid catabolic process

Across TCGA cell cohorts, RNA activity of the Phospholipid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AAMDC, DYSF, and C20orf96, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipid catabolic process activity versus AAMDC in BLOOD_Leukemia (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AAMDC →	+0.674	+0.143	.001	<.001	3	5
URINARY_TRACT	DYSF →	-3.132	-0.306	.004	.006	3	5
BLOOD_Leukemia	C20orf96 →	+0.559	+0.145	.006	.005	3	5
LUNG_SCLC	ARHGAP39 →	+0.875	+0.191	.002	<.001	3	5
CNS	CHD3 →	+0.631	+0.285	<.001	.002	2	6
STOMACH	NFIC →	+1.897	+0.337	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009395 vs AAMDC — BLOOD_Leukemia

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