Oligosaccharide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Oligosaccharide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG10, RAB27A, and RPRM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligosaccharide biosynthetic process activity versus ATG10 in LSCC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ATG10 →	-0.307	-0.443	.003	.003	3	4
GBM	RAB27A →	+0.469	+0.182	.001	.002	3	4
GBM	RPRM →	-1.294	-0.201	.003	<.001	3	4
COAD	SS18L1 →	-0.414	-0.242	.006	.009	3	4
GBM	NCAPD3 →	-0.443	-0.177	.003	<.001	3	4
GBM	GK-IT1 →	+0.675	+0.145	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009312 vs ATG10 — LSCC

Explore this scatter interactively →