Oligosaccharide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Oligosaccharide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FARSA, POF1B, and RTN4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FARSA grouped by Oligosaccharide biosynthetic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FARSA →	-0.798	-0.613	<.001	.008	3	4
LIVER	POF1B →	+3.798	+0.652	<.001	.002	3	4
STOMACH	RTN4 →	-0.882	-0.436	.001	<.001	3	4
LARGE_INTESTINE	WDR83OS →	-0.492	-1.184	<.001	.001	3	3
LARGE_INTESTINE	TAF8 →	-0.562	-0.982	.003	.004	2	4
STOMACH	PEA15 →	-1.089	-0.348	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FARSA by Oligosaccharide biosynthetic process activity — SOFT_TISSUE

Explore this box plot interactively →