Oligosaccharide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Oligosaccharide biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB21, CHD1, and DSC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB21 grouped by Oligosaccharide biosynthetic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RAB21 →	-0.305	-0.178	<.001	<.001	3	5
CNS	CHD1 →	+0.220	+0.108	.004	.004	3	5
BREAST	DSC3 →	-0.156	-0.087	<.001	<.001	3	4
BLOOD_Leukemia	CPB2 →	+0.179	+0.139	.006	.001	3	4
LUNG_NSCLC_LUSC	ITGAV →	+0.806	+0.171	<.001	.009	3	4
LUNG_NSCLC_LUSC	PRSS38 →	-0.381	-0.168	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB21 by Oligosaccharide biosynthetic process activity — SOFT_TISSUE

Explore this box plot interactively →