Oligosaccharide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Oligosaccharide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALT1, SLC35G1, and LAMP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligosaccharide biosynthetic process activity versus B4GALT1 in CNS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	B4GALT1 →	+1.054	+1.064	.001	.001	3	4
BONE	SLC35G1 →	-0.847	-0.422	.009	.004	3	4
OVARY	LAMP2 →	+0.821	+1.027	<.001	<.001	3	4
PANCREAS	RNF125 →	-0.913	-1.421	.008	<.001	3	4
PANCREAS	ARHGDIB →	+3.515	+1.367	.006	.003	3	4
CNS	NAF1 →	-0.611	-1.138	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009312 vs B4GALT1 — CNS

Explore this scatter interactively →