Oligosaccharide metabolic process

Across TCGA patient cohorts, RNA activity of the Oligosaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMNDC1, MLPH, and CD2AP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligosaccharide metabolic process activity versus SMNDC1 in GBM (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMNDC1 →	-0.315	-0.183	.004	<.001	3	4
OV	MLPH →	+1.274	+0.208	<.001	.001	3	4
GBM	CD2AP →	+0.476	+0.156	.001	.006	3	4
LSCC	NUP107 →	-0.439	-0.162	<.001	<.001	3	4
GBM	RAB37 →	+0.347	+0.137	.001	<.001	3	4
LSCC	CMSS1 →	-0.522	-0.145	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009311 vs SMNDC1 — GBM

Explore this scatter interactively →