Oligosaccharide metabolic process

Across TCGA cell cohorts, RNA activity of the Oligosaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCTD14, IFT27, and LPCAT3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCTD14 grouped by Oligosaccharide metabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KCTD14 →	-2.160	-0.309	.002	.007	3	4
OVARY	IFT27 →	+1.234	+0.586	<.001	.006	3	3
OVARY	LPCAT3 →	+0.799	+0.682	.008	.001	3	3
OVARY	PREX1 →	-1.344	-0.556	.002	.009	3	3
SKIN	RAB11FIP1 →	-0.517	-0.570	.003	.009	3	3
LUNG_SCLC	SPAST →	-0.809	-0.573	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCTD14 by Oligosaccharide metabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →