Oligosaccharide metabolic process

Across TCGA cell cohorts, RNA activity of the Oligosaccharide metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPB2, SP4, and BAX, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPB2 grouped by Oligosaccharide metabolic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CPB2 →	+0.169	+0.086	.001	<.001	3	5
CNS	SP4 →	+0.129	+0.090	.002	<.001	3	5
PANCREAS	BAX →	-0.249	-0.103	.001	<.001	3	4
LUNG_SCLC	MLX →	+0.229	+0.115	.001	<.001	3	4
LUNG_SCLC	KANSL3 →	-0.371	-0.102	.007	.004	3	4
KIDNEY	TIMM10 →	+0.456	+0.133	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPB2 by Oligosaccharide metabolic process activity — BLOOD_Leukemia

Explore this box plot interactively →