Oligosaccharide metabolic process

Across TCGA cell cohorts, RNA activity of the Oligosaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRAS, CTBS, and SDF4, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligosaccharide metabolic process activity versus RRAS in LUNG_SCLC (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RRAS →	+2.393	+0.096	.001	<.001	3	12
BONE	CTBS →	+1.027	+0.106	<.001	<.001	3	11
BONE	SDF4 →	+0.710	+0.117	.007	.003	3	10
SOFT_TISSUE	SIL1 →	+1.097	+0.106	<.001	<.001	3	10
BONE	P4HA1 →	+1.669	+0.141	<.001	<.001	3	10
BONE	MAN2B2 →	+1.116	+0.112	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009311 vs RRAS — LUNG_SCLC

Explore this scatter interactively →