Oligosaccharide metabolic process

Across TCGA cell cohorts, RNA activity of the Oligosaccharide metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TREML2, USH1C, and OR5R1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TREML2 grouped by Oligosaccharide metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TREML2 →	+0.185	+0.881	.003	.002	3	4
BLOOD_Leukemia	USH1C →	-0.255	-1.276	.006	.007	2	5
CNS	OR5R1 →	-0.315	-1.849	.006	<.001	3	3
LARGE_INTESTINE	UQCRC1 →	+0.361	+1.565	<.001	<.001	3	3
LARGE_INTESTINE	KCNJ2 →	-0.141	-1.129	<.001	<.001	3	3
LARGE_INTESTINE	GJD3 →	-0.140	-0.888	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TREML2 by Oligosaccharide metabolic process activity — BREAST

Explore this box plot interactively →