Oligosaccharide metabolic process

Across TCGA cell cohorts, RNA activity of the Oligosaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAA, NAF1, and IKZF5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligosaccharide metabolic process activity versus GAA in SKIN (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GAA →	+0.814	+0.590	.005	.006	3	5
BONE	NAF1 →	-0.936	-1.394	.005	.004	2	6
BLOOD_Lymphoma	IKZF5 →	-0.831	-1.272	<.001	<.001	3	4
SOFT_TISSUE	ZYG11A →	+1.457	+1.550	<.001	<.001	3	4
OESOPHAGUS	ACHE →	+1.253	+1.184	<.001	.002	3	4
SKIN	HNRNPR →	-0.482	-0.946	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009311 vs GAA — SKIN

Explore this scatter interactively →