Amine catabolic process

Across TCGA patient cohorts, RNA activity of the Amine catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAOB, SORBS1, and SYNPO2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amine catabolic process activity versus MAOB in OV (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MAOB →	+0.877	+0.065	<.001	<.001	3	8
COAD	SORBS1 →	+0.794	+0.055	<.001	<.001	3	7
COAD	SYNPO2 →	+0.808	+0.050	<.001	<.001	3	7
CCRCC	TNS2 →	+0.386	+0.069	<.001	.001	3	7
UCEC	DMD →	+0.565	+0.095	<.001	<.001	3	7
GBM	HNMT →	+0.583	+0.092	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009310 vs MAOB — OV

Explore this scatter interactively →