Amine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Amine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL1RL1, SPDL1, and KIF20A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amine biosynthetic process activity versus IL1RL1 in CCRCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	IL1RL1 →	+1.149	+0.144	<.001	<.001	3	5
UCEC	SPDL1 →	-0.456	-0.095	.005	<.001	3	5
GBM	KIF20A →	-0.702	-0.132	<.001	.002	3	5
GBM	CCNB1 →	-0.653	-0.121	.001	.005	3	5
GBM	LMNB1 →	-0.584	-0.106	.001	.001	3	5
GBM	RRM2 →	-0.610	-0.095	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009309 vs IL1RL1 — CCRCC

Explore this scatter interactively →