Amine metabolic process

Across TCGA patient cohorts, RNA activity of the Amine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUV39H2, NCAPG, and NCAPH, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amine metabolic process activity versus SUV39H2 in LSCC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SUV39H2 →	-0.760	-0.128	<.001	.004	3	8
GBM	NCAPG →	-0.831	-0.150	<.001	<.001	3	7
GBM	NCAPH →	-0.740	-0.138	<.001	<.001	3	7
GBM	CENPE →	-0.753	-0.141	<.001	<.001	3	6
GBM	BUB1 →	-0.810	-0.149	<.001	<.001	3	6
GBM	TUBB →	-0.641	-0.224	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009308 vs SUV39H2 — LSCC

Explore this scatter interactively →