Amine metabolic process

Across TCGA cell cohorts, RNA activity of the Amine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FNDC7, MTMR11, and ERCC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FNDC7 grouped by Amine metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FNDC7 →	-0.057	-0.513	.003	.006	3	3
KIDNEY	MTMR11 →	+1.228	+0.887	.008	.009	3	3
OESOPHAGUS	ERCC1 →	+0.713	+0.165	<.001	.006	3	3
OESOPHAGUS	PROSER3 →	+1.448	+0.231	<.001	<.001	3	3
OESOPHAGUS	PPM1N →	+1.323	+0.197	<.001	<.001	3	3
OESOPHAGUS	ZNF225 →	+0.511	+0.191	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FNDC7 by Amine metabolic process activity — SKIN

Explore this box plot interactively →