Amine metabolic process

Across TCGA cell cohorts, RNA activity of the Amine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM216A, ECI2, and ARHGAP27, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amine metabolic process activity versus FAM216A in CNS (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FAM216A →	+0.837	+0.263	.002	.001	3	5
PANCREAS	ECI2 →	+1.474	+0.844	<.001	.009	3	5
CNS	ARHGAP27 →	-1.342	-0.316	.001	<.001	3	4
PANCREAS	SMS →	+1.594	+1.074	<.001	.003	3	4
BLOOD_Leukemia	PRRG2 →	-0.251	-0.163	.002	.009	3	4
LUNG_SCLC	OCLN →	-1.193	-0.286	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009308 vs FAM216A — CNS

Explore this scatter interactively →