tRNA transcription

Across TCGA patient cohorts, RNA activity of the tRNA transcription pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB7, KIF22, and POLL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA transcription activity versus PSMB7 in OV (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PSMB7 →	+0.533	+0.161	.003	.008	3	5
GBM	KIF22 →	+0.398	+0.150	<.001	.003	3	5
BRCA	POLL →	+0.462	+0.566	.001	.001	3	4
BRCA	CNTROB →	+0.479	+0.699	.001	.001	3	4
BRCA	KIF24 →	+0.409	+0.473	.001	.003	3	4
BRCA	NEURL4 →	+0.591	+0.642	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009304 vs PSMB7 — OV

Explore this scatter interactively →