tRNA transcription

Across TCGA cell cohorts, RNA activity of the tRNA transcription pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RARS2, ARL5B, and HRK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RARS2 grouped by tRNA transcription-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RARS2 →	-0.393	-0.137	.004	.009	2	5
SOFT_TISSUE	ARL5B →	-0.405	-0.066	.002	.006	3	4
BREAST	HRK →	+0.275	+0.060	.001	.005	3	4
CNS	DDX18 →	+0.189	+0.060	<.001	<.001	3	4
SKIN	POU4F3 →	+0.133	+0.047	.002	.001	3	3
BLOOD_Leukemia	MTIF2 →	-0.246	-0.084	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RARS2 by tRNA transcription activity — LUNG_SCLC

Explore this box plot interactively →