tRNA transcription

Across TCGA cell cohorts, RNA activity of the tRNA transcription pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP4, TAF4B, and WDCP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA transcription activity versus LRP4 in BREAST (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LRP4 →	+1.540	+1.037	<.001	<.001	3	6
BREAST	TAF4B →	+1.547	+0.898	<.001	.005	3	5
BREAST	WDCP →	+0.625	+0.862	.001	.001	3	5
BREAST	ZFYVE19 →	-0.698	-0.627	<.001	.004	3	5
LIVER	FAM161A →	+1.159	+1.261	<.001	<.001	3	5
OVARY	ANG →	-0.979	-0.754	.009	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009304 vs LRP4 — BREAST

Explore this scatter interactively →