snRNA transcription

Across TCGA patient cohorts, RNA activity of the snRNA transcription pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC6, KIF18B, and HROB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA transcription activity versus CDC6 in PDAC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CDC6 →	+0.848	+0.784	<.001	<.001	3	6
PDAC	KIF18B →	+0.813	+1.038	<.001	<.001	3	6
PDAC	HROB →	+0.378	+0.555	<.001	<.001	3	6
PDAC	TOP2A →	+0.846	+0.936	<.001	<.001	3	5
UCEC	CCDC150 →	+0.666	+0.580	.007	.001	2	6
GBM	NCAPH →	+0.625	+0.651	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009301 vs CDC6 — PDAC

Explore this scatter interactively →