Cellular response to starvation

Across TCGA cell cohorts, RNA activity of the Cellular response to starvation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TM7SF3, ABCC4, and TXLNG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TM7SF3 grouped by Cellular response to starvation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TM7SF3 →	-0.748	-0.177	.006	<.001	3	4
OVARY	ABCC4 →	+1.539	+0.176	.001	.003	3	3
OESOPHAGUS	TXLNG →	+0.717	+0.166	.004	.009	3	3
OESOPHAGUS	DZANK1 →	-1.061	-0.229	.002	.001	3	3
BLOOD_Leukemia	ACADM →	+0.997	+0.170	.005	.002	2	4
BLOOD_Leukemia	NSL1 →	+0.918	+0.123	.006	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TM7SF3 by Cellular response to starvation activity — BREAST

Explore this box plot interactively →