Response to temperature stimulus

Across TCGA patient cohorts, RNA activity of the Response to temperature stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADPRH, RASSF5, and STAT5A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to temperature stimulus activity versus ADPRH in LSCC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADPRH →	+0.306	+0.021	.001	.004	3	6
GBM	RASSF5 →	+0.475	+0.036	<.001	<.001	3	6
LSCC	STAT5A →	+0.408	+0.038	<.001	<.001	3	5
GBM	ACAP1_T739 →	+0.786	+0.032	<.001	.002	3	5
LSCC	SPN_S355 →	+0.653	+0.019	.001	.006	3	5
GBM	THEMIS2_T593 →	+0.507	+0.044	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009266 vs ADPRH — LSCC

Explore this scatter interactively →