Deoxyribonucleotide catabolic process

Across TCGA cell cohorts, RNA activity of the Deoxyribonucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LCMT2, C14orf119, and DYRK1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LCMT2 grouped by Deoxyribonucleotide catabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LCMT2 →	-1.170	-1.194	<.001	.002	3	4
CNS	C14orf119 →	+0.654	+1.062	<.001	<.001	3	4
LUNG_SCLC	DYRK1A →	-1.011	-1.180	<.001	.004	3	4
LARGE_INTESTINE	TMED8 →	+0.764	+1.115	.005	.005	3	4
LARGE_INTESTINE	DLST →	+0.766	+1.823	.002	<.001	3	4
BLOOD_Leukemia	TMEM251 →	-1.092	-1.376	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LCMT2 by Deoxyribonucleotide catabolic process activity — OVARY

Explore this box plot interactively →