Deoxyribonucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Deoxyribonucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIGZ, MRPS27, and UBR7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIGZ grouped by Deoxyribonucleotide metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PIGZ →	+1.146	+0.247	.005	.005	3	4
PANCREAS	MRPS27 →	-0.968	-0.188	<.001	.006	3	3
URINARY_TRACT	UBR7 →	-1.205	-0.172	.008	<.001	3	3
URINARY_TRACT	THAP4 →	-1.004	-0.170	<.001	<.001	3	3
URINARY_TRACT	TMPRSS2 →	+1.893	+0.123	.006	.004	2	4
URINARY_TRACT	ECI2 →	-1.599	-0.159	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIGZ by Deoxyribonucleotide metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →