Ribonucleotide catabolic process

Across TCGA patient cohorts, RNA activity of the Ribonucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HERC1, NPTN-IT1, and ATG2B, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleotide catabolic process activity versus HERC1 in UVM (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	HERC1 →	+0.886	+0.027	<.001	<.001	3	30
TGCT	NPTN-IT1 →	+0.847	+0.033	<.001	<.001	3	30
THYM	ATG2B →	+0.959	+0.042	<.001	<.001	3	30
SARC	PDE4D →	+1.237	+0.027	<.001	<.001	3	29
THYM	APAF1 →	+1.455	+0.042	<.001	<.001	3	29
THYM	VPS13C →	+1.268	+0.044	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009261 vs HERC1 — UVM

Explore this scatter interactively →