Glucan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glucan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHA4, C3orf49, and HOMER3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLEKHA4 grouped by Glucan biosynthetic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PLEKHA4 →	+1.053	+1.275	.005	.001	3	4
PANCREAS	C3orf49 →	-0.098	-1.680	<.001	<.001	3	4
BLOOD_Lymphoma	HOMER3 →	-3.689	-1.825	.001	<.001	3	4
BONE	COPZ1 →	+0.575	+1.090	.001	.009	3	4
STOMACH	NIPA1 →	-0.711	-1.385	.009	.001	2	5
OVARY	UGGT2 →	-0.827	-1.061	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLEKHA4 by Glucan biosynthetic process activity — KIDNEY

Explore this box plot interactively →