Protein lipoylation

Across TCGA patient cohorts, RNA activity of the Protein lipoylation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC20A1, USP27X-AS1, and LINC01550, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein lipoylation activity versus SLC20A1 in BRCA (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC20A1 →	-0.345	-0.083	.009	.002	3	4
CCRCC	USP27X-AS1 →	+0.230	+0.095	<.001	<.001	3	4
OV	LINC01550 →	+0.571	+0.153	<.001	.004	3	4
UCEC	GOSR1 →	-0.521	-0.104	.003	.002	3	3
BRCA	IGFLR1 →	-0.362	-0.083	.001	.002	3	3
BRCA	AKR1C1 →	+1.038	+0.080	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009249 vs SLC20A1 — BRCA

Explore this scatter interactively →